Participants

 

The ReAd Marie Curie Initial Training Network interconnects the following participants:

 

Sijbren OttoSijbren Otto (Rijksuniversiteit Groningen, NL, www.otto-lab.com) is associated with the Centre for Systems Chemistry of the University of Groningen in the Netherlands. The Otto group works on various aspects of Systems Chemistry and Supramolecular Chemistry, including dynamic combinatorial chemistry and self-replication. We are also working towards application in the areas of catalysis and biomolecule recognition using functionalised nanoparticles.

 

Gonen AshkenasyGonen Ashkenasy (Ben Gurion University of the Negev, Beer Sheva, IL, www.bgu.ac.il/~gonenash) The main research effort in our lab is devoted to the design and synthesis of multi-component chemical systems, termed as molecular networks, and for analysis of their dynamic self-organization. This study, which can be entitled as ‘Systems Chemistry’, is inspired by the complexity and high-order observed by molecular networks within cells. Our findings can be used for understanding the organizational principles of biological systems, to shine light on plausible scenarios in early molecular evolution and the origins of life, and to develop devices of nanotechnology and biotechnology importance. We use peptides and proteins as the active components in these studies, and thus the observed structure-function relationships are further interpreted for understanding fundamental processes, such as protein folding and protein interactions with small molecules and bio-macromolecules.

 

Nicolas GiusepponeNicolas Giuseppone (University of Strasbourg/CNRS, FR, www-ics.u-strasbg.fr/...) received his PhD from Orsay University (2000), working in the laboratory of Prof. H. B. Kagan. He then moved to The Scripps Research Institute as a postdoctoral associate in the group of Prof. K. C. Nicolaou. In 2002, as a CNRS junior scientist, he joined the laboratory of Prof. Jean-Marie Lehn in Strasbourg where he defended his Habilitation (2005). He became Full Professor of Chemistry in 2007 at the University of Strasbourg and he created the SAMS research group at the Institut Charles Sadron (ICS). In 2010, he was awarded the ERC Starting Grant from the European Research Council, and has become deputy director of the ICS from January 2012.
The topic of the present research project within the ITN READ network will combine dynamic combinatorial libraries and self-replicating systems in the field of organic supramolecular electronics. The general framework will be to develop a selection process directly related to the conducting functionality of new supramolecular objects and to correlate their emerging properties with the electronic transfer phenomena. The required building blocks will be synthesized and the self-assemblies of the various components will be characterized as isolated species by all the advanced techniques used in soft-matter science. Their conduction properties will be evaluated using field effect transistor and OPVs set-ups. The final steps of the project will concern the selective self-fabrication of the conducting structures from mixtures, in situ within electronic devices, and in order to close a metallic circuitry by a smart process.

 

Douglas PhilpGünter von Kiedrowski (Ruhr Universität Bochum, DE, www.ruhr-uni-bochum.de/oc1/kiedro.html). The von Kiedrowski group initiated the field of chemical self-replicating systems and introduced early examples for self-replicating molecular networks. The group also pioneered the programmable self-assembly of three-dimensionally defined nano-objects from trisoligonucleotides. The groups currently focusses on the coupling and integration of autocatalytic reactions based on chemical self-replication, autocatalytic compartimentation, metabolic autocatalysis and organoautocatalysis, chiral symmetry breaking, and informational nanotechnology, which is one of the goals of the emergent field of “systems chemistry”, a  term coined by the group in 2005.

 

Douglas PhilpDouglas Philp (University of St. Andrews, UK, ch-www.st-and.ac.uk/staff/dp/group) A key component of systems chemistry will be the development of synthetic machinery that is capable of directing its own synthesis and co-operating with other similar systems to create an organized hierarchy or network. A fundamental understanding of recognition-mediated processes that allow molecules to function as specific and efficient templates for the formation of themselves (autocatalysis) and other templates (crosscatalysis) should permit the development of efficient protocols that allow us to establish and manage replication, organization and evolution within complex chemical systems. This programmed systems behavior can ultimately be exploited in the construction, selection and amplification of large molecular and supramolecular assemblies. We are exploiting our interest in recognition-mediated reactivity and in replication processes to create synthetic metabolic pathways that can operate autonomously and respond to discrete template-based instructions.

 

Leonard PrinsLeonard Prins (University of Padova, IT, www.chimica.unipd.it/leonard.prins) Our group is interested in the use of dynamic combinatorial chemistry for catalyst development relying on the self-selection of functional groups by an analogue of the transition state of a chemical reaction. A second major research line is dedicated to the use of functionalized nanoparticles for the construction of supramolecular peptide-nanoparticle systems. These systems are used for the recognition of biologically relevant targets and for the development of enzyme assays relying on catalytic signal amplification. 

 

 

Kay SeverinKay Severin (Ecole Polytechnique Féderale de Lausanne, CH, lcs.epfl.ch/severin) Research in the laboratory of Kay Severin is focused on the synthesis of functional nanostructures and on the development of sensors and catalysts.

 

 

 

 

 

 

Rein UlijnRein Ulijn (University of Strathclyde, UK, www.ulijnlab.com) The work in our group is focused on the development of materials that mimic the adaptive properties of biological systems. These adaptive mechanisms are underpinned by complex molecular networks, which combine self-assembly, compartmentalization, gelation and catalysis to achieve various functions. These functions include encoding, logic operations, molecular recognition, adaption, motility and ultimately evolution. Synthetic materials with these properties open up new applications in wide ranging areas ranging from biomedicine to nanotechnology.

 

 

Marc-André DelsucMarc-André Delsuc (NMRTEC SAS, FR, Private Enterprise, www.nmrtec.com) Working as a biophysicist, I am passionate about developing new concepts and applying new methodologies to complex chemical and biological problems tackled at the molecular level. Recently I have mostly concentrated my research on the analysis of Intrinsically Disordered Proteins. The study of the specific behaviour of these newly discovered objects requires a challenging and innovative approach to various analytical spectroscopies. I share my time between the IGBMC institute and the NMRTEC company.
NMRTEC has been playing an essential role in the development of innovative NMR analysis of materials for over 10 years.
From the beginning, we have concentrated on developing creative solutions to a range of problems in the industrial and biotechnological fields.
NMRTEC expertise and problem solving capabilities stem from a wide industry knowledge combined with an in-depth understanding of NMR science, e.g. MaxEnt/ILT algorithm, optimized sequences and spectrometers, dedicated and proprietary probes. Our activities include complex validation studies, characterization analysis and exploratory projects.

 

Marc-André Delsuc

Hilmar Rauhe (Informium AG, DE, Private Enterprise, www.informium.com) invented DNA cryptography in 1998/1999. Informium AG was founded in 2001 to make use of this molecular encryption technology for the purpose of anti-counterfeiting and brand protection. Since then the company developed several innovations in the area of tagging and identification of products and works for several well-known companies worldwide.

 

 

 


 

Ludovic JullienLudovic Jullien (Ecole Normale Supérieure, FR, Associated Partner, www1.chimie.ens.fr/Imsmo) The Jullien's group is concerned with engineering and observing complex dynamic behaviour in systems submitted to chemical reactions, matter/heat diffusion, and action of fields. Its expertise covers Photoactive organic molecules, Photophysics/photochemistry, Analytical Chemistry, Chemical Thermodynamics/Kinetics, Microsystems. In the present action, Prof. Jullien will participate to training on photophysics/photochemistry and on the design/realization of microsystems for observing complex behaviour in reactive systems.

 

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