Selected Publications

Systems chemistry G. Ashkenasy, T. M. Hermans, S. Otto, A. F. Taylor, Chem. Soc. Rev. 2017,
46, 2543.


Transient compartmentalization of RNA replicators prevents extinction due to parasites.
S. Matsumura, A. Kun, M. Ryckelynck, F. Coldren, A. Szilágyi, F. Jossinet, C. Rick, P. Nghe, E.
Szathmáry, A. D. Griffiths, Science, 2016, 354, 1293.


Transient assembly of active materials fueled by a chemical reaction. J. Boekhoven, W.E.
Hendriksen, G.J.M. Koper, R. Eelkema, J.H. van Esch, Science, 2015, 349, 1075.


Diversification of self-replicating molecules. J. W. Sadownik, E. Mattia, P. Nowak, S. Otto,
Nature Chem. 2016, 8, 264.


Dissipative self-assembly of vesicular nanoreactors. S. Maiti, I. Fortunati, C. Ferrante, P.
Scrimin, L. J. Prins, Nature Chem. 2016, 8, 725.


Enzymatic reactions in confined environments. A. Küchler, M. Yoshimoto, S. Luginbühl, F.
Mavelli, P. Walde, Nature Nanotechn. 2016, 11, 409.


Emergent catalytic behavior of self-assembled low molecular weight peptide-based
aggregates and hydrogels. M. Tena-Solsona, J. Nanda, S. Diaz-Oltra, A. Chotera, G. Ashkenasy,
B. Escuder, Chem. Eur. J. 2016, 22, 6687.


Common origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism. B.
H. Patel, C. Percivalle, D. J. Ritson, C. D. Duffy, J. D. Sutherland, Nature Chem. 2015, 7, 301.


The systems perspective at the crossroads between chemistry and biology. A. de la Escosura,
C. Briones, K. Ruiz-Mirazo, J. Theor. Biol. 2015, 381, 11.


Stability and its manifestation in the chemical and biological worlds. R. Pascal, A. Pross,
Chem. Commun. 2015, 51, 16160.

J. M. Rib, C. Blanco, J.Crusats, Z. El-Hachemi, D. Hochberg, A. Moyano Absolute Asymmetric Synthesis in Enantioselective Autocatalytic Reaction Networks: Theoretical Games, Speculations on Chemical Evolution and perhaps a Synthetic Option. Chem Eur. J. 2014, 20, 1-23.

H. Fanlo-Virgós, A.N.R. Alba, S. Hamieh, M. Colomb-Delsuc, S. Otto Transient Substrate-Induced Catalyst Formation in a Dynamic Molecular Network. Angew. Chem. Int. Ed.  2014, 126, 11528 –11532.

J. Li, P. Nowak, H. Fanlo-Virgos, S. Otto Catenanes from Catenanes: Quantitative Assessment of Cooperativity in Dynamic Combinatorial Catenation Chem. Sci.  2014, 5, 4968-4974.

A. Le Chevalier Isaad, P. Car­rara, P. Stano, K.S. Krishnakumar, D. Lafont, A. Zamboulis, R. Buchet, D. Bouchu, F. Albrieux, P. Strazewski. A hy­d­ro­pho­bic disordered peptide spon­taneously anchors a co­valently bound RNA hairpin to giant lipi­d­ic vesi­cles. Org. Biomol. Chem. 2014, 12(33), 6363-73.

Y. Ruff., V. Garavini, N. Giuseppone, Reversible Native Chemical Ligation: a Facile Access to Dynamic Covalent Peptides J. Am. Chem. Soc., 2014, 136 (17), 6333–6339.
Highighted in: Nature SciBX, 2014, 7(18); doi:10.1038/scibx.2014.537

P Walde, H, Umakoshi P Stano, and F Mavelli. Emergent properties arising from the assembly of amphiphiles. Artificial vesicle membranes as reaction promoters and regulators. Chem. Comm. 2014, 50, 10177-10197.

S Tanaka,. H., Fellerman S. Rasmussen Structure and selection in an autocatalytic binary polymer model. EPL 2014, 107, 28004.

D. Beaufils, G. Danger, L. Boiteau, J. C. Rossi, and R. PascalDiastereoselectivity in 5(4H)-oxazolone-mediated prebiotically relevant peptide coupling Chem. Comm., 2014, 50, 3100–3102.

R. Pascal, A. Pross and J. D. SutherlandTowards an Evolutionary Theory of the Origin of Life Based on Kinetics and Thermodynamics Open Biology, 2013, 3, 130156.


Books and Book Chapters

P. Strazewski. RNA as major components in chemical evolvable systems (chapter 1, pp 1–24), in: Chemical Biology of Nucleic Acids: Fundamentals and Clinical Applications. V. A. Erdmann, W. T. Markiewicz, J. Bar­ci­szew­ski (eds.). Series: RNA Technologies. V. A. Erdmann, J. Barciszewski (series eds.), Springer 2014.

P. Strazewski. Amphiphilic peptidyl-RNA, in: DNA in Supramolecular Chemistry and Nano­tech­no­logy. E. Stulz, G. H. Clever (eds), Wiley 2014.


Media and Outreach

Interview "7 questions to Prof. Strazewski" published (in Polish) in the May issue of "Wiedza i Życie" ("Knowledge and Life").

Prof. Strazewski on YouTube "No RNA World without Peptides and Lipids" a scientific meeting in November 2013 in Poznań, Poland:

Dr J. Howse, Dr A.F. Taylor and artist Mark Fell turned the Arts Tower into a 255-foot art installation using computer controlled lighting to display simulations of complex chemical reactions reactions:

Prof. Kepa Ruiz-Mirazo’s blog entry:




COST Action

General Information
Start Date: 3-12-2013
End Date: 2-12-2017

Action Chair:
Prof. Sijbren Otto

Vice Chair:
Prof. Gonen Ashkenasy

STSM Manager:
Prof. Kepa Ruiz-Mirazo

Dissemination Manager:
Prof. Annette Taylor

Science Officer:
Dr. Lucia Forzi

Administrative Officer:
Ms. Svetlana Voinova